JCO Oncology Practice: https://ascopubs.org/doi/10.1200/OP-25-00618
This topic is not discussed enough in the clinic. Most of us are not sure about the answers. Also the topic is awkward. A Journal of Oncology Practice article (2016) published a survey of cancer survivors. It found that 46% reported sexual health problems related to the diagnosis and treatment of cancer. Additionally, 71% said they had received no care for sexual dysfunction. There is a significant gap in knowledge and resources in this area.
This is a good article giving simple guidelines.
The gist of the article is:
- Sexual health remains important for quality of life during cancer treatment
- Evidence for strict sexual restrictions in neutropenia is limited
- Stable monogamous partners: condoms not routinely required if partner healthy
- Avoid anal sex/fecal exposure, new partners, or sex during severe mucositis
- Gentle hygiene is sufficient; over-washing may harm mucosa
- Condoms may be used briefly after chemotherapy to protect partners from drug exposure
- Counseling should be individualized and evidence-informed, not based on outdated blanket restrictions.
Table: Sexual Health Guidance During Neutropenia and Immunosuppression

JCO Oncology Practice: https://ascopubs.org/doi/10.1200/OP-25-00618
It is important to talk about:
Fertility and contraception: Use reliable barrier methods or other contraception. Discuss fertility preservation early.
Emotions: Several patients notice changes in desire, body image, or function (dryness, erectile issues, pain).
Partner perspective: The healthy partner should be reassured that risk to them is low with basic precautions.
Intimacy is still possible and often beneficial. It is important to review the person’s situation and give clear and practical guidance for the patient and their partner.